Stilbenoids such as mulberroside A, oxyresveratrol, and resveratrol are important compounds used as quality markers for mulberry extract. They have properties that promote skin clarity and antioxidant effects. Typically, methanol is commonly used as a solvent for extracting these compounds from mulberry due to its efficiency. However, due to safety concerns and the difficulty in removing residual toxic substances, methanol is not suitable for cosmetics or dietary supplement formulations. Researchers have therefore developed a highly efficient ultrafiltration solvent system capable of extracting high levels of stilbenoid compounds from mulberry, comparable to methanol, while demonstrating skin-brightening properties, confirming the efficacy of the extract.